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Image Search Results
Journal: Journal of Neuroscience
Article Title: Dopamine Acts as a Partial Agonist for 2A Adrenoceptor in Melanin-Concentrating Hormone Neurons
doi: 10.1523/jneurosci.6245-10.2011
Figure Lengend Snippet: Figure 2. Dopamine acts as a partial agonist of 2A receptors. A, Summary of DA-induced currentsinthepresenceofDAor2antagonist.DAeffectisblockedby2(yohimbin)and2A antagonist (BLR44405), but not by DA antagonists (LE300 and/or sulpiride). Ineffectiveness of D1- and D2-like agonists is also shown (SKF81297 quinpirole). DA effect persists in the dopamine--hydroxylase inhibitor fusaric acid. **p 0.01 versus DA 100 M, ANOVA with Dunnett’s posttest. ns, Not significant. B, NE response is also inhibited by BLR44408. ***p 0.0005,unpairedttest.C,Concentration–responsecurveforDA(n3–8)andNE(n5–6), demonstrating that DA is a partial agonist. Numbers in bar graphs indicate cell numbers included.
Article Snippet: Tertiapin-Q,
Techniques: Concentration Assay